Fatty acid metabolic reprogramming via mTOR-mediated ... - Nature
网页2016年11月30日 · Here, we show that the mTORC1–PPARγ pathway is crucial for the fatty acid uptake programme in activated CD4 + T cells. This pathway is required for full activation and rapid proliferation of...
Major involvement of mTOR in the PPARγ-induced stimulation of adipose ...
网页Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulator of adiposity, yet its involvement as a mediator of the positive actions of peroxisome proliferator-activated receptor (PPAR)γ agonism on lipemia, fat accretion, lipid uptake, and its major determin ….
Fatty acid metabolic reprogramming via mTOR-mediated ... - PubMed
网页2016年11月30日 · Here, we show that the mTORC1-PPARγ pathway is crucial for the fatty acid uptake programme in activated CD4 + T cells. This pathway is required for full activation and rapid proliferation of naive and memory CD4 + T cells. PPARγ directly binds and induces genes associated with fatty acid uptake in …
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ
网页2022年12月7日 · Peroxisome proliferator-activated receptor-gamma (PPARγ) is a prototypical metabolic nuclear receptor involved in neural differentiation and axon polarity. The JAK-STAT, mTOR, and PPARγ signaling pathways serve as a highly conserved signaling hub that coordinates neuronal activity and brain development.
PPAR control of metabolism and cardiovascular functions
网页2021年6月14日 · Peroxisome proliferator-activated receptors (PPARs) are fatty acid sensors that regulate whole-body metabolism. Activation of PPARγ (for example, by glitazones)...
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ
网页Peroxisome proliferator-activated receptor-gamma (PPARγ) is a prototypical metabolic nuclear receptor involved in neural differentiation and axon polarity. The JAK-STAT, mTOR, and PPARγ signaling pathways serve as a highly conserved signaling hub that coordinates neuronal activity and brain development.
Major involvement of mTOR in the PPARγ-induced stimulation of …
网页Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulator of adiposity, yet its involvement as a mediator of the positive actions of peroxisome proliferator-activated receptor (PPAR)γ agonism on lipemia, fat accretion, lipid uptake, and its major determinant lipoprotein lipase (LPL) remains to be eluc...
Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell …
网页2019年4月25日 · Fibroblast mTOR/PPARγ/HGF axis promotes tubular cell survival. Previous studies demonstrated that PPARγ functions as one of the major downstream molecules of mTOR signaling .
PPAR-γ Modulators as Current and Potential Cancer Treatments
网页2021年9月23日 · This review aims to consolidate the functions of PPAR-γ, the current and potential applications of PPAR-γ modulators, and the challenges in applying PPAR-γ modulators to cancer treatment, in both laboratory and clinical settings.
HIF-1α–PPARγ–mTORC1 signaling pathway-mediated ... - Springer
网页2023年8月29日 · HIF-1α–PPARγ–mTORC1 pathway-mediated autophagy plays a critical role in the inflammatory response of pancreatic cells in HLAP, and interference with the HIF-1α–PPARγ–mTOR pathway can serve as a new strategy for …
- 某些结果已被删除