Ovariectomized rat model of osteoporosis: a practical guide
网页2020年1月10日 · The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of OVX, (3) selection of an appropriate surgical method and verification of OVX, and (4) evaluation of OVX-induced osteoporosis.
小鼠卵巢摘除模型OVX（骨质疏松）构建细节 - 知乎
网页2023年7月1日 · 小鼠卵巢摘除（ovariectomy，简称ovx）是一个较成熟的动物模型，通过双侧卵巢摘除术可以成功建立模拟雌激素缺乏而导致的骨质疏松动物模型。 卵巢所在位置 图源网络. 模型制备. 经腹腔注射戊巴比妥钠进行麻醉. 麻醉起效后将小鼠仰卧位放置于手术板上，对背部进行脱毛. 用手术剪沿背部中线作一长约0.5-1cm的皮肤切口，钝性分离皮肤和肌肉. 从创口可以看到肌层，在离脊柱1cm肋下剪开腰肌，立即可见包绕卵巢的脂肪组织及卵 …
Ovariectomized rat - Wikipedia
网页An ovariectomized rodent (OVX) is a female rat or mouse whose ovaries have been removed. Currently, there is no single animal model that precisely replicates the stages of osteoporosis in humans, [1] although there are some animals that are relatively close and can be used for comparative purposes.
The Ovariectomized Mice and Rats | SpringerLink
网页2011年1月1日 · As early as 1985, ovariectomized (OVX) rats were used to study postmenopausal osteoporosis. The most common animals that are used for experimental studies are rodents, mainly rats and mice. Osteoporosis-related research is no exception.
Ovariectomized rat model of osteoporosis: a practical guide
网页2020年1月10日 · The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of OVX, (3) selection of an appropriate surgical method and verification of OVX, and (4) evaluation of OVX-induced osteoporosis.
The Ovariectomized Rat as a Model for Studying Alveolar Bone …
网页2015年4月28日 · The ovariectomized (OVX) rat model is the approved preclinical model by the Food and Drug Administration (FDA) for studying how the decline in endogenous estrogen production by the ovaries at menopause leads to postmenopausal osteoporosis and how potential interventions can preserve bone metabolism in this state.
Utility of the Ovariectomized Rat as a Model for Human …
网页Ovariectomy-induced osteopenia in the rat produces skeletal responses similar to that in a post-menopausal woman. In the ovariectomized (ovx) rat, high bone turnover, and subsequent bone loss, like in the human post-menopausal condition, can be prevented by estrogen replacement.
Ovariectomized rats as a model of postmenopausal osteoarthritis ...
网页2004年2月19日 · We aimed to assess the effect of ovariectomy on cartilage turnover and degradation, to evaluate whether ovariectomized (OVX) rats could form an experimental model of postmenopausal osteoarthritis. The effect of ovariectomy on cartilage was studied using two cohorts of female Sprague–Dawley rats, aged 5 and 7 months.
The magnitude and rate of bone loss in ovariectomized mice …
网页The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed tomography (micro-CT) to examine the skeletal response to OVX and patterns of change in three inbred strains of mice.
Early effects of ovariectomy on bone microstructure, bone …
网页2022年4月2日 · In this study, the ovariectomized rat model was used to simulate the postmenopausal state of women. We aimed to explore the early manifestations of estrogen deficiency in rats’ axial bone and peripheral bone by micro-CT combined with BTMs and mechanical properties.
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