Nuclear mRNA decay: regulatory networks that control gene
网页2024年4月18日 · Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adaptation to internal and environmental cues.
Mechanisms of nuclear mRNA export: a structural perspective
网页Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene expression. As mRNA is synthesized, it is packaged with a myriad of RNA-binding proteins to form ribonucleoprotein particles (mRNPs). For each step in the processes of maturation and export, mRNPs must have the correct complement of proteins.
Genome organization around nuclear speckles drives mRNA
网页2024年5月8日 · Nuclear speckles are shown to have a functional role in mRNA splicing, whereby dynamic three-dimensional organization of DNA around these structures mediates splicing efficiency.
The Great Escape: mRNA Export through the Nuclear Pore Complex
网页2021年10月29日 · Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA is not translocated on its own, but it forms ribonuclear particles (mRNPs) in association with proteins that are crucial for its …
Extracellular mRNA transported to the nucleus exerts translation ...
网页2021年6月16日 · ZC3H12D recruited to the cell membrane binds to the 3′-untranslated region of nex-IL1β-mRNA and transports it to the nucleus. The nex-IL1β-mRNA in the NK cell nucleus upregulates...
Nuclear Export of Messenger RNA - PMC - National Center for ...
网页2015年3月31日 · Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends.
Into the basket and beyond: the journey of mRNA through the …
网页2020年1月17日 · Numerous proteins have important roles in the transport of mRNA out of the nucleus. The NPC embedded in the nuclear envelope is the port of exit for mRNA and is composed of ∼30 unique proteins, nucleoporins, forming the distinct structures of the nuclear basket, the pore channel and cytoplasmic filaments.
The dynamic lifecycle of mRNA in the nucleus - PubMed
网页The mRNA molecule roams through the nucleus on its way out to the cytoplasm. mRNA encounters and is bound by many protein factors, from the moment it begins to emerge from RNA polymerase II and during its travel in the nucleoplasm, where it will come upon chromatin and nuclear bodies.
Mechanism of mRNA transport in the nucleus - PubMed
网页2005年11月22日 · Using molecular beacons to track single mRNA molecules in living cells, we have characterized the diffusion of mRNP complexes in the nucleus. The mRNP complexes move freely by Brownian diffusion at a rate that assures their dispersion throughout the nucleus before they exit into the cytoplasm, even when the transcription site is located near ...
Structural basis of mRNA maturation: Time to put it together
网页2022年8月1日 · Messenger RNA (mRNA) is the carrier of genetic information from DNA to protein. In eukaryotes, mRNA expression begins in the cell nucleus with precursor mRNA (pre-mRNA) transcription and continues with several …
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