Nucleic acid analogue - Wikipedia
网页Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research. Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pentose sugar, either ribose or deoxyribose, and one of four nucleobases.
Nucleobase-modified nucleosides and nucleotides: Applications …
网页2022年11月30日 — Nucleobase-modified nucleoside analogs as probes for DNA polymerase activity and fidelity. Hydrogen-Bonding Interactions Are Not Essential for DNA Polymerization.
Practical and concise synthesis of nucleoside analogs
网页2022年7月4日 — This novel methodology addresses several longstanding challenges in nucleoside analog synthesis; 10 direct access to C3′/C5′ protected and C4′ functionalized nucleoside analogs such as ...
Fluorescent nucleobases as tools for studying DNA and RNA
网页2017年10月16日 — Fluorescent nucleobases are chemically modified DNA and RNA analogues that not only retain their chemical and biological functionalities, such as stacking, base pairing and enzyme...
Nucleobase and Nucleoside Analogues: Resistance and Re …
网页2018年7月23日 — Nucleobase and nucleoside analogues exert their cytotoxic effects by mimicking endogenous nucleosides (and following phosphorylation, nucleotides). This can either be mediated by enzyme inhibition or by substituting endogenous nucleoside species as substrates, leading to DNA and RNA damage and interference with DNA methylation.
Frontiers | Nucleobase-modified nucleosides and nucleotides ...
网页2022年11月29日 — Recent results highlight the ability to combine nucleobase-modified nucleosides with anti-cancer agents that damage DNA as a new therapeutic strategy to improve the overall efficacy and safety of existing chemotherapeutic agents. Nucleobase-modified nucleoside analogs as probes for DNA polymerase activity and fidelity
网页Nucleoside analogs are valuable commodities in the development of antisense oligonucleotides or as stand-alone antiviral and anticancer therapies. Syntheses of nucleoside analogs are typically...
Nucleoside Analogs: A Review of Its Source and Separation …
网页2023年10月12日 — Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation.
Site-specific incorporation of a fluorescent nucleobase analog …
网页2024年2月16日 — The cytosine analog 1,3-diaza-2-oxophenoxazine (tC O) is a fluorescent nucleobase able to form either hemiprotonated base pairs with cytosine residues, or neutral base pairs with guanines. We show here that when tC O is incorporated in the proximity of a G:C:G:C minor groove tetrad, it induces a strong thermal and pH stabilization, resulting in ...
Nucleobase Analogue - an overview | ScienceDirect Topics
网页Spontaneous assemblages of nucleobase or nucleobase-analogue derivatives through hydrogen bonding have received great interest to tailor well-defined molecular assemblies. For nucleobase-bearing chromophores, specific interchromohore behavior was controlled by molecular recognition in organic media [1] .