GSDME-mediated pyroptosis promotes the progression and
网页2023年2月18日 — Caspase 3/GSDME axis after NLRP3 activation has been identified as “a salvage inflammatory pathway” when the canonical NLRP3-GSDMD signaling is blocked. GSDME may serve as a potential ...
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial …
网页2021年12月8日 — Genetic KO of GSDMD, Casp-1, and astrocytic NOD-like receptor protein 3 (NLRP3) inflammasome in mice alleviated depression-like behaviors and inhibited the pyroptosis-associated protein expression.
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial
网页2021年12月8日 — Genetic KO of GSDMD, Casp-1, and astrocytic NOD-like receptor protein 3 (NLRP3) inflammasome in mice alleviated depression-like behaviors and inhibited the pyroptosis-associated protein expression. In contrast, overexpression of astrocytic GSDMD-N-terminal domain (GSDMD-N) in the hippocampus could …
The multifaceted roles of GSDME-mediated pyroptosis in cancer
网页2023年12月16日 — When GSDME expression is high, cisplatin and paclitaxel activate the caspase-3/GSDME pathway, convert normal chemotherapy-induced apoptosis into pyroptosis and inhibit lung cancer cell growth .
NLRP3 inflammasome activation triggers gasdermin D …
网页2021年10月22日 — Sustained NLRP3 inflammasome induced caspase-8/-3 and GSDME cleavage and IL-1β maturation in vitro in Gsdmd−/− macrophages. Thus, a salvage inflammatory pathway involving caspase-8/-3–GSDME was activated after NLRP3 activation when the canonical NLRP3-GSDMD signaling was blocked.
Caspase 3/GSDME-dependent pyroptosis contributes to …
网页2021年2月15日 — Pyroptosis can be induced by caspase 4 and 5 (in humans) or caspase 11 (in mice) activation via GSDMD cleavage, leading to cell bubbling and the release of IL-1β 21, 36 – 38. Recently discovered caspase 3/GSDME signaling was also reported to be one of the signaling mechanisms for cell pyroptosis 14, 28, 39 – 41.
Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic …
网页2022年12月2日 — Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and Gsdmd, fails to block pyroptosis and cytokine release. To clarify the molecular mechanism of silicosis pathogenesis for new therapy, we examined samples from silicosis patients and genetic mouse models.
The caspase-3/GSDME signal pathway as a switch between
网页2020年10月28日 — Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor...
Caspase-3/GSDME mediated pyroptosis: A potential
网页2023年11月1日 — Wang et al. generated mice and macrophages with constitutive activation of Nlrp3 (Nlrp3 CA) through Gain-of-function mutations. They observed that stimulation with LPS could induce the activation of caspase-8/3 and GSDME in bone marrow-derived macrophages (BMDMs) from Nlrp3 CA/+;Gsdmd −/− …
GSDME-Dependent Incomplete Pyroptosis Permits Selective IL …
网页2020年5月22日 — In the present study, we found that NLRP3 inflammasome activation induces delayed necrotic cell death via ASC in caspase-1/11-deficient macrophages. Furthermore, ASC-mediated caspase-8 activation and subsequent gasdermin E processing are necessary for caspase-1-independent necrotic cell death.