Study finds a new line of drugs to stimulate myelin repair in multiple ...
网页2021年8月24日 · A study by Gladstone Institutes reveals a new line of drugs that can overcome the toxic effect of fibrinogen, a blood-clotting protein that leaks into the brain and blocks myelin repair in...
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating …
网页2022年9月1日 · In this research, we examined the therapeutic effects of the Bu Shen Yi Sui capsule (BSYS), a traditional Chinese medicine prescription, in a cuprizone- (CPZ-) triggered demyelination model of MS (CPZ mice). This research intended to evaluate if BSYS might promote remyelination by shifting A1 astrocytes to A2 astrocytes. Methods.
An atlas for human brain myelin content throughout the adult …
网页2021年1月11日 · Myelin water imaging (MWI) is a quantitative magnetic resonance imaging (MRI) technique that uses a multi-echo T 2 relaxation sequence to characterize myelin 1.
Myelin plasticity in the ventral tegmental area is required ... - Nature
网页2024年6月5日 · We demonstrate that dopaminergic neuronal activity-regulated myelin plasticity is a key modulator of dopaminergic circuit function and opioid reward.
Myelin Repair Provides Novel Multiple Sclerosis Treatment
网页2024年5月2日 · Researchers discovered a promising treatment for MS using a protein function inhibitor, ESI1, that reactivates the brain’s capacity to produce myelin, a crucial protective coating on nerve cells. The study showcases that ESI1 enhances myelin sheath production and improves neurological functions in mice and human brain cells, suggesting potential for human clinical trials.
Bu-Shen-Yi-Sui Capsule, an Herbal Medicine Formula, Promotes
网页2020年7月22日 · The results showed that BSYSC treatment significantly improved the body weight and clinical scores of EAE mice, alleviated inflammatory infiltration and nerve fiber injury, protected the ultrastructural integrity of the myelin sheath, and significantly increased the expression of myelin basic protein (MBP) in EAE mice.
CD11c + microglia promote white matter repair after ischemic stroke
网页2023年2月24日 · We found that CD11c+ microglia increased from Day 7 to Day 30, demonstrating high phagocytotic capabilities, myelin-supportive genes, and lipid metabolism associated genes.
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating …
网页The activation of astrocytes exerts double-edged sword effects, which perform an integral function in demyelination and remyelination. In this research, we examined the …
Study shows promise in repairing damaged myelin - ScienceDaily
网页2019年4月18日 · Jan. 13, 2021 — A compound appears to protect nerve fibers and the fatty sheath, called myelin, that covers nerve cells in the brain and spinal cord. The new research in a mouse model advances ...
MS: New drug may help regenerate myelin, potentially heal nerve …
网页2024年8月9日 · A study reveals a drug that can block a receptor protein and enhance the regeneration of myelin around nerve cells in MS. The drug, PIPE-307, has shown promise in animal and human trials and may...