『珍藏版』阴阳相济的中庸之道——AMPK和mTORC1营养感知与 …
网页AMP能够结合AMPK的γ亚基，引起AMPK全酶，特别是α亚基上变构，从而促进T172位点的暴露使之更容易被LKB1所磷酸化。. 同时，AMP还能够保护T172磷酸化不被磷酸酶所去除，以及直接通过别构激活的方式数倍地提高AMPK的活力。. 上述的由LKB1和AMP所代表的“ …
mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis …
网页The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in response to diverse stimuli such as variations in amino acid content, changes in cellular bioenergetics, oxygen levels, neurotrophic factors and xenobiotics.
AMPK and mTOR in cellular energy homeostasis and drug targets
网页The AMP-activated protein kinase (AMPK) is a cellular energy sensor and signal transducer that is regulated by a wide array of metabolic stresses. These two pathways serve as a signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth, and dysregulation of each pathway may contribute to …
How does mTOR sense glucose starvation? AMPK is the usual …
网页2020年4月22日 · The current model is that AMPK inhibits mTORC1 in response to glucose starvation through the phosphorylation and activation of the mTOR negative regulator tuberous sclerosis complex 2 (TSC2) 18 ...
Balancing the Activation of mTOR and AMPK: Anabolism and …
网页2023年11月6日 · AMPK and mTOR are two metabolic pathways at the heart of our metabolism. When one is switched “on” the other tends to be “off.” AMPK activation is associated with an unusually long lifespan – mTOR, with the growth of skeletal muscle and with a robust immune response.
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing ... - PubMed
网页2020年3月3日 · The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of nutrients and energy and regulation of cell growth. AMPK (Yin, or the "dark side") is switched on by lack of energy or nutrients and inhibit ….
A systems study reveals concurrent activation of AMPK and mTOR ... - Nature
网页2016年11月21日 · We report that AMP-activated protein kinase (AMPK), phosphatidylinositide 3-kinase (PI3K) and mTOR complex 2 (mTORC2) are acutely activated by aa-readdition in an mTORC1-independent manner.
mTORC1 directly inhibits AMPK to promote cell proliferation …
网页2020年1月20日 · This study establishes reciprocal regulation between the two key nutrient sensors in cells, mTORC1 and AMPK, showing that mTORC1 directly inhibits AMPK by phosphorylation at S345 in the AMPK ...
Cross-talk between AMPK and mTOR in regulating energy balance
网页Recent research demonstrated the possible interplay between mTOR and AMPK signaling pathways. In this review, we will present current knowledge of AMPK and mTOR pathways in regulating energy balance and demonstrate …
Computational modeling of AMPK and mTOR crosstalk in
网页2023年7月17日 · In this work, we use computational modeling to explore how the calcium-AMPK-mTOR signaling axis could couple neuronal energy states and mTOR activity. Computational modeling has vastly contributed ...
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