MASP2 (protein) - Wikipedia
网页Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. [5][6][7] Function. The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by …
补体药新靶点MASP-2：首款抗体药商业化在即，国内上市公司
网页2022年11月18日 · 奥麦罗制药（以下简称Omeros）的Narsoplimab为目前临床进度最领先的MASP-2抗体候选药物，是一款全人源IgG4单抗，正在进行造血干细胞移植相关血栓性微血管病（HSCT-TMA）、IgA肾病、非典型溶血性尿毒症综合征（aHUS）、狼疮性肾病等适应症的多项临床研究。 Narsoplimab临床进度. 针对Narsoplimab首个适应症HSCT-TMA， Omeros公司于今年4月在ASCO官方期刊Journal of Clinical Oncology (JCO)上在线发表 …
MASP2：药物靶点与生物标志物的新一代生物学研究方法
网页MASP2作为一种新型药物靶点，在药物研发和生物医学研究中具有重要价值。. 本文首先综述了MASP2的结构、功能及与药物靶点相互作用的基本原理，然后探讨了MASP2在药物靶点筛选、药物化学合成以及生物医学研究中的应用前景，最后对未来MASP2研究的发展进行了 ...
Mannan-binding lectin serine protease-2 (MASP-2) in human
网页2022年9月24日 · An in-house mouse monoclonal antibody targeting the SP-domain of MASP-2 (Fig. 2 A,B) was used. It was raised against a human MASP-2 peptide aa575-584 LTQRGFLAR coupled to diphteria toxoid and...
MASP-2 - 维基百科，自由的百科全书
网页甘露糖结合凝集素丝氨酸蛋白酶2 （Mannan-binding lectin serine protease 2，也被称为 甘露糖相关丝氨酸蛋白酶2，mannose-associated serine protease 2，缩写MASP-2）是由人类基因 MASP2 编码的一种酶。 [1] [2] [3]
Targeting the Complement Serine Protease MASP-2 as a …
网页2021年2月17日 · MASP-2 plays a central role in the lectin pathway of complement activation, as its proteolytic activity is responsible for the cleavage of the complement elements C2 into C2a (a function shared with MASP-1), and C4 into C4b. Once cleaved, C2a and C4b are responsible for converting the complement factor C3 into its active form C3b . MASP-2 ...
Targeting the Complement Serine Protease MASP-2 as a
网页2021年2月17日 · MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading t ….
MASP-2 Is a Heparin-Binding Protease; Identification of Blocking ...
网页2020年4月28日 · Our data show that highly sulfated GAGs mediated inhibition of all three complement pathways, whereas short heparin- and heparan sulfate-derived oligosaccharides selectively blocked the lectin pathway via MASP-2 inhibition.
Mannan-binding lectin-associated serine protease-2 (MASP-2
网页2014年3月24日 · MASP-2 is responsible for activation of complement factors C4 and C2. MASP-2 is composed of six domains: CUB1, EGF, CUB2, CCP1, CCP2 and the serine protease domain. 1. The afore-mentioned...
网页MASP-2 is activated when the PRMs bind to carbohydrate residues on microorganisms or “stressed” epithelial cells, leading to potential complement-system-mediated elimination or dysfunction of ...