Pharmacokinetics and tissue distribution of two novel isomerism ...
网页LLC-0601 (S,S) and LLC-0601 (R,R) are two novel synthesized isomerism platinum compounds both with encouraging anticancer activity. However, the previous study showed that toxicity of LLC-0601 (R,R) was much higher than that of LLC-0601 (S,S) with higher body weight loss and mortality rate of tested rat ….
新型铂类化合物LLC-0601与舒铂对SD大鼠的肝毒性
网页恢复期顺铂组病理组织学病变较给药末期重，出现延迟性毒性反应，其余各给药组各项检测指标均基本恢复。 结论 顺铂、舒铂和llc-0601均可引起大鼠肝损伤，其机制与药物引起的组织过氧化损伤有关。
网页LLC060170mg·kg－1组肝病理组织学均出现不同程度肝细胞点灶状坏死，肝窦内淋巴细胞浸润，以舒铂组 病变程度最重。恢复期顺铂组病理组织学病变较给药末期重，出现延迟性毒性反应，其余各给药组各项检测 指标均基本恢复。
Hepatotoxicity of heptaplatin and a new platinum complex LLC-0601 …
网页2011年8月1日 · Liver tissue in cisplatin, heptapletin and LLC-0601 70 mg·kg -1 groups showed focal necrosis and sinusoidal lymphocytic infiltration of liver cells. After 28 d restoration all indices returned to...
Pharmacokinetics and Tissue Distribution of Two Novel …
网页2016年4月4日 · LLC-0601 (S,S) and LLC-0601 (R,R) are two novel synthesized isomerism platinum compounds both with encouraging anticancer activity. However, the previous study showed that toxicity of...
A . DNA adduct formation with platinum compounds having …
网页LLC-0601(S,S) and LLC-0601(R,R) are two novel synthesized isomerism platinum compounds both with encouraging anticancer activity.
云南省铂类抗癌新药临床前预研究取得重要进展 - 生物通
网页昆明贵金属研究所与中国科学院上海药物研究所等通过合作研究，发明了治疗胃癌铂类新化合物llc－0601，并开展了规范的临床前预研究。 通过研究表明，LLC-0601显示出了新一代铂类化学新药良好的开发前景。
新型铂类化合物LLC-0601与舒铂对SD大鼠的肝毒性_参考网
网页本实验旨在对llc-0601与已上市且结构相似的舒铂进行肝毒性比较研究，为llc-0601的临床研究和开发提供实验依据。 1 材料与方法 1.1 动物. spf级sd大鼠，雄性，50只，体质量200～250 g。来源于昆明医学院实验动物中心，动物许可证号:scxk(滇)2005-0008。
Synthesis and anticancer activity of a new water-soluble derivative …
网页2014年6月22日 · In this study, we reported LLC-1403, a novel water-soluble analogue of heptaplatin and also a prodrug for LLC-0601. It features 3-acetoxyl-cyclobutane-1,1-dicarboxylate as the leaving group and is endowed with good water solubility and stability.
LLC-0601 MeSH Supplementary Concept Data 2024
网页LLC-0601(R,R) LLC-0601(S,S) Registry Number 0 Heading Mapped to *Organoplatinum Compounds Frequency 2 Note structure in first source Source Inorg Chem. 2011 Jun 20;50(12):5324-6 Date of Entry 2011/09/29 Revision Date 2017/03/24. Expand All. LLC-0601 Preferred. LLC ...
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