组蛋白H4第12位赖氨酸乳酸化修饰正向反馈调控小胶质细胞 - 知乎
网页运用H4K12la与神经元、星形胶质细胞和小胶质细胞的标记物抗体进行免疫荧光共染以及蛋白质印迹法分析组蛋白乳酸化水平，结果表明，H4K12la是5×FAD小鼠脑内斑块邻近的小胶质细胞中最普遍受影响的组蛋白乳酸化修饰（图1D-G）。 图1 组蛋白乳酸化在5×FAD小鼠和AD患者脑组织中增加. 糖酵解/H4K12la/PKM2在AD小鼠的小胶质细胞中形成正反馈循环. 随后作者观察到在5×FAD小鼠的小胶质细胞中，随着AD发病的进展，糖酵解基因Hif-1α、Pkm2 …
KMT9 monomethylates histone H4 lysine 12 and controls ... - Nature
网页2019年5月6日 · KMT9, a new histone lysine methyltransferase targeting H4K12, is enriched at promoters of genes encoding molecules involved in the cell cycle and controls the growth of androgen receptor ...
Histone H4K12 - EpiGenie
网页Histone H4K12 Function. Recently it has been shown that H4K12ac is important in paternal influence on early gene expression in the zygote. Sperm chromatin is packaged with protamines instead of histones for the majority (85%) of …
Deciphering histone H4 lysine acetylation and methylation via …
网页2023年11月15日 · Here we report a novel semisynthesis method of histone H4 via SML, which allowed us to prepare nucleosomes containing multivalently modified histone H4 for investigations of histone deacetylation by sirtuins.
Lactylproteome analysis indicates histone H4K12 lactylation as a …
网页2024年5月7日 · We observed that lactylation modification of histone H4K12 was higher in cancer tissues compared to adjacent controls. Aligning with sequencing analysis, the basal expression level of histone H4 protein remained unchanged in TNBC versus controls.
Histone lactylation dynamics: Unlocking the triad of metabolism ...
网页2024年8月28日 · Histone lactylation suggests poor prognosis and highlights a suppressive tumor immune environment in PDAC. •. The axis involving LDHA-H4K12la-immuno-genes operates in immune evasion to promote the progression of PDAC. •. Elevated histone lactylation in liver metastasis increases Nectin-2-mediated immune evasion through a positive feedback loop.
Real-Time Imaging of Histone H4K12–Specific Acetylation …
网页Histone acetylation constitutes an epigenetic mark for transcriptional regulation. Here we developed a fluorescent probe to visualize acetylation of histone H4 Lys12 (H4K12) in living cells using fluorescence resonance energy transfer (FRET) and the binding of the BRD2 bromodomain to acetylated H4K12.
Real-time imaging of histone H4K12-specific acetylation ... - PubMed
网页2011年4月22日 · Histone acetylation constitutes an epigenetic mark for transcriptional regulation. Here we developed a fluorescent probe to visualize acetylation of histone H4 Lys12 (H4K12) in living cells using fluorescence resonance energy transfer (FRET) and the binding of the BRD2 bromodomain to acetylated H4K1 ….
Histone H4 Lysine 12 Acetylation Regulates Telomeric ... - PLOS
网页2011年1月13日 · Histone H4K12 acetylation facilitates basal transcription at telomeric heterochromatin. Previous work had shown that histone H4 mutations that led to increased telomere position effect (TPE) were usually associated with …
Real-Time Imaging of Histone H4K12–Specific Acetylation …
网页2011年4月22日 · By utilizing the bromodomain region of BRD2, which specifically recognizes K12-acetylated histone H4, we developed a probe for visualizing acetylation of histone H4K12, named Histac-K12. Using Histac-K12, we demonstrated that H4K12 acetylation is retained during mitosis in living cells.