HPMCAS_化工百科 - ChemBK
网页中文名:醋酸酯化丁二酸氢酯化的纤维素-2-羟基丙基甲基醚,英文名:acetic acid, methanol, propane-1,2-diol, succinic acid,CAS:71138-97-1,化学式:C10H22O9,分子量:286.276,熔点:>203°C (dec.),沸点:236.1°C at 760 mmHg,闪点:110.9°C,蒸汽压:0.0165mmHg at …
Hydroxypropyl methylcellulose acetate succinate as an exceptional ...
网页2022年8月1日 · HPMCAS is an effective polymer for the creation of ASD with dual functionality: solubilization of poorly soluble drugs, promotion of rapid dissolution in the intestinal medium, and prevention of subsequent precipitation of drugs by maintaining supersaturation concentration of the drug molecules.
AquaSolve™醋酸羟丙甲纤维素琥珀酸酯-亚什兰中国
网页药用AquaSolve™醋酸羟丙甲纤维素琥珀酸酯（HPMCAS）是一种纤维素类聚合物，包含有4个在羟基上的随机取代的基团，质量百分比分别为：甲氧基，12-18wt%；羟丙基，4-23wt%；乙酰基，2-16wt%以及琥珀酰基，4-28wt%。. 它是一种白色或类白色，略有醋酸味 …
Hydroxypropylmethylcellulose Acetate Succinate - an overview ...
网页Hydroxypropylmethylcellulose Acetate Succinate. HPMCAS (here on often referred as AS) is an enteric polymer composed of cellulose back bone with a substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups (Fig. 2).
聚合物HPMCAS是固体分散体开发中最耀眼的“明珠”？_药融云
网页HPMCAS具有两亲性，乙酰基疏水性基团可与难溶性药物产生疏水结合，琥珀酰基亲水性基团有利于在水性介质中形成稳定的胶束；在pH5以上环境中HPMCAS会电离，电荷有利于维持药物载体胶束的稳定，故HPMCAS能有效维持药物的过饱和浓度，抑制药物的重结晶。 综上，具有独特属性的HPMCAS非常适合难溶性药物固体分散体的制备。 图2 HPMCAS化学结构 (来源于参考2) HPMCAS具有独特的性质，特别适合在固体分散体开发中使用，那么下面 …
Emerging Applications of Hydroxypropyl Methylcellulose Acetate ...
网页Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of disso...
固体分散体：HPMCAS-SDDs增强低水溶性药物口服吸收 - 知乎
网页HPMCAS-SDDs可以用来提高低溶解性药物的口服吸收，它是指将HPMCAS用于喷雾干燥来制备固体分散体 (SDDs)。 形成的固体分散体为药物和HPMCAS形成的无定形。 在调研的近130种模型药物，HPMCAS-SDDs在生物模拟液中溶解度明显高于单纯的药物无定形。 并且大多数模型药物形成的HPMCAS-SDDs在两年时间的长期稳定性中，无定形保持稳定，未发现重结晶。 低溶解性药物值得开发的原因与增溶面对的困难. 许多低溶解性药物虽然不符 …
Properties and Applications of Hypromellose Acetate Succinate (HPMCAS ...
网页2013年10月11日 · With the increased use of amorphous dispersions, hypromellose acetate succinate (HPMCAS) has emerged as a commonly used excipient for formulation design. This unique material, originally designed to enhance thermoplastic properties of cellulosics, can be used to enhance the solubility of …
Impact of Hydroxypropyl Methylcellulose Acetate Succinate Critical ...
网页2021年11月5日 · Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is widely used in ASDs due to its hydrophobic/hydrophilic balance and ionizability of the substituent functionalities.
Hydroxypropyl Methylcellulose Acetate Succinate: Potential Drug ...
网页2008年8月29日 · Hydroxypropyl methylcellulose acetate succinate (hypromellose acetate succinate, HPMC-AS, Fig. 1 a) is an enteric coating material developed for both regular enteric coating and sustained release formulations. Recently, HPMC-AS was also used in new technologies such as solid dispersion (1).