Nature | 丁璟珒与邵峰团队破解GSDMB可变剪接调控细胞焦亡活性 …
网页北京生命科学研究所/清华大学生物医学交叉研究院邵峰团队在2020年发现，细胞毒性淋巴细胞分泌的颗粒酶A (GZMA) 特异地切割和活化靶细胞内gasdermin家族的成员GSDMB，通过GSDMB N端结构域的膜打孔活性引起靶细胞焦亡 (1)。. 2021年一篇发表在Cell上的研究报道 …
Science | 邵峰：GSDMB被颗粒酶激活进而诱导靶细胞发生焦亡
网页2020年4月20日 · 该研究发现在细胞毒性淋巴细胞杀伤靶细胞的过程中，细胞毒性淋巴细胞来源的Granzyme A蛋白能够特异地高效激活Gasdermin B (GSDMB) 蛋白，从而导致靶细胞发生细胞焦亡，该分子机制能够.
Structural mechanisms for regulation of GSDMB pore-forming …
网页2023年3月29日 · Different cancer cell lines have markedly different isoform compositions, correlating with the onset and extent of pyroptosis following GZMA stimulation. Our study illustrates fine regulation of ...
GSDMB is increased in IBD and regulates epithelial …
网页2022年1月20日 · Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is known about its functional relevance during active disease states.
GSDMB is increased in IBD and regulates epithelial …
网页2022年1月11日 · Currently, no treatment modalities exist that specifically enhance and/or improve gut barrier function; however, the intestinal epithelium represents a promising therapeutic target for IBD that remains a very active area of research and development (Odenwald and Turner, 2017).
鼩鼱（哺乳纲食虫目鼩鼱科动物）_百度百科
网页鼩鼱等食虫类是最早的有胎盘类动物，产生于中生代的白垩纪，大多数是以昆虫为食的小动物，也是哺乳动物中最原始的一类。 [9]鼩鼱能消灭一部分害虫，对农林有利。 其掘土活动对森林土壤的改良和森林更新起一定作用。 [8] 中文名. 鼩鼱. 别 名. 尖嘴鼠、食虫鼠、臭老鼠. 界. 动物界. 门. 脊索动物门. 亚 门. 脊椎动物亚门. 纲. 哺乳纲.
(PDF) Giant Sb metallogenic belt in South China: A product of Late ...
网页2022年1月7日 · A simplified geological map of the giant Sb metallogenic belt in South China (GSMB) showing the structural framework and distribution of major Sb deposits in the GSMB (modified from Peng and Hu...
Geological Survey & Mines Bureau - GSMB
网页Geological Survey & Mines Bureau. About us. News Highlights. Issuance of Mining License to Lankan Resource Mining Pvt. Ltd. for Graphite Extraction in Kalutara District - Thursday, 08 August 2024 05:01.
A simplified geological map of the giant Sb metallogenic belt in …
网页Download scientific diagram | A simplified geological map of the giant Sb metallogenic belt in South China (GSMB) showing the structural framework and distribution of major Sb deposits in the...
Giant Sb metallogenic belt in South China: A product of Late …
网页The giant Sb metallogenic belt in South China (GSMB) has been proved to provide approximately half the world’s reserves and Sb production. This metallogenic belt is tectonically located along the transition zone between the Yangtze and Cathaysia blocks, covering an area of ∼ 1900 km long and ∼ 200 km wide, with a set of large or giant Sb ...
跳至内容