Endothelial Cell Apoptosis | Circulation Research - AHA/ASA Journals
网页2012年12月7日 · Endothelial cells (ECs) covering the inner surface of blood and lymphatic vessels 1 create an interface between circulating blood and lymph and the surrounding tissue. Hence, ECs are crucially involved in maintaining the integrity of all tissues.
Understanding endothelial cell apoptosis: what can the …
网页2007年8月8日 · Endothelial cell (EC) apoptosis may play an important role in blood vessel development, homeostasis and remodelling. In support of this concept, EC apoptosis has been detected within remodelling vessels in vivo, and inactivation of EC apoptosis regulators has caused dramatic vascular phenotypes.
The quiescent endothelium: signalling pathways regulating organ ...
网页2021年2月24日 · Indeed, endothelial cell-specific deletion of Akt1 in mice with global Akt2 deletion alters Jagged 1–Notch signalling between endothelial and mural cells, leading to apoptosis of vascular...
Endothelial dysfunction: mechanisms and contribution to diseases
网页2024年5月21日 · Recent studies on endothelial dysfunction have mainly focused on inflammatory signaling in ECs (initiated by different stimuli such as LPS), impaired endothelial cytoskeleton/the ECM, and the...
Endothelial Apoptosis - CHEST
网页Endothelial apoptosis can be found in a number of diseases. This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.
Endothelial cell apoptosis and the role of endothelial cell-derived ...
网页2018年12月19日 · Endothelial cell apoptosis can occur in response to risk factors for atherosclerosis including elevated plasma LDL and glucose levels, or natural physiological processes such as shear stress and ROS. These observations highlight the importance of further investigating the consequences of endothelial cell death in atherosclerosis.
The role of endothelial cell apoptosis in inflammatory and immune ...
网页In this review, we focus on the potential role of endothelial apoptosis in the initiation and progression of inflammatory and immune disorders, reviewing human diseases and in vivo models in which endothelial cell apoptosis has been demonstrated.
Endothelial cells and pulmonary arterial hypertension: apoptosis ...
网页2009年10月13日 · Apoptotic endothelial cells may release some kinds of factors that generate apoptosis-resistant proliferative endothelial cells, promote vascular smooth muscle cell proliferation and result in subsequent selection of progenitor-like cells leads to endothlial-mesenchymal (SM-like) transdifferentiation.
Endothelial Apoptosis - ScienceDirect
网页2000年3月1日 · This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.
The role of endothelial cell apoptosis in inflammatory and immune ...
网页2005年8月1日 · In this review, we focus on the potential role of endothelial apoptosis in the initiation and progression of inflammatory and immune disorders, reviewing human diseases and in vivo models in which endothelial cell apoptosis has been demonstrated. Although endothelial cell apoptosis is observed in many inflammatory and …
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