Dicoumarol - Wikipedia
网页Dicoumarol is a natural chemical substance of combined plant and fungal origin. It is a derivative of coumarin, a bitter-tasting but sweet-smelling substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds or silages by a number of species of fungi, into active dicoumarol.
双香豆素 - 百度百科
网页双香豆素为维生素K拮抗剂，为口服抗凝血药。. 其作用是通过与维生素K发生竞争性抑制，阻碍维生素K依赖性凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ的合成，从而起抗凝血作用。. 但双香豆素对已形成的这些凝血因子无作用，因此应用双香豆素后待血中这些凝血因子耗竭后才可 ...
Dicoumarol (Dicumarol，双香豆素) - 仅供科研 | PDHK抑制剂 | MCE
网页Dicoumarol 是 NAD (P) H:quinone oxidoreductase 1 (NQO1) 和 PDK1 的抑制剂，IC 50 分别为 0.37±0.15 和 19.42±0.032 μM。. Dicoumarol 以剂量依赖性方式抑制 PDK1 活性。. 当用 200 μM Dicoumarol 处理时，PDK1 的酶活性降低了大约 94%。.
Dicoumarol: from chemistry to antitumor benefits - PMC
网页2022年12月27日 · Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades.
Dicoumarol: Uses, Interactions, Mechanism of Action - DrugBank …
网页Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). Mechanism of action.
Dicumarol | C19H12O6 | CID 54676038 - PubChem
网页2010年4月29日 · Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases. DrugBank. Dicumarol has been reported in Homo sapiens and Viola arvensis with data available.
Dicoumarin - SpringerLink
网页2018年11月20日 · Dicoumarin, a coumarin derivative, is an oral anticoagulant drug, and its common mechanism is to inhibit synthesis of the coagulation factor in the liver. There are many coumarin derivatives, and the most common clinical drug is warfarin, which is applicable to long-term maintenance of anticoagulant.
Dicoumarol: from chemistry to antitumor benefits - PubMed
网页2022年12月27日 · Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists' attention, aiming its synthesis and of dicoumar ….
Dicoumarol: from chemistry to antitumor benefits
网页2022年12月27日 · Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades.
A pharmacological review of dicoumarol: An old natural anticoagulant ...
网页2020年10月1日 · Dicoumarol is an oral anticoagulant agent prescribed in clinical for decades. It is a natural hydroxycoumarin discovered from the spoilage of Melilotus officinalis (L.) Pall and is originally discovered as a rodenticide.