Circulating tumor cells: biology and clinical significance
网页2021年11月22日 · Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of...
Circulating tumor cells shielded with extracellular vesicle-derived ...
网页2024年4月5日 · Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during...
Circulating tumor cells: from new biological insights to clinical ...
网页2024年9月2日 · The progression of cancer from a localized tumor to a widespread metastatic disease is a complex and multifaceted process, making it cancer patients’ leading cause of death. 1 The driving...
Vimentin and cytokeratin: Good alone, bad together
网页2022年11月1日 · Epithelial-like cancer cells express cytokeratin (red), which aids in stress resistance and supports cell-cell adhesion; these cells do not express vimentin. As cells progress through EMT, mesenchymal markers such as …
Clinical Significance of Cytokeratin 20-Positive Circulating Tumor ...
网页2009年2月2日 · Our work has shown that the number of preoperation cytokeratin (CK) 20-positive circulating tumor cells (pCTC) is correlated with tumor-node-metastasis stage and lymph node status in colorectal cancer patients.
Circulating cytokeratin 18 fragments and activation of dormant tumor …
网页2010年1月1日 · Evidence for such a role of bone marrow BM-DTCs or circulating tumor cells has been confirmed for breast cancer patients, where BM-positive patients have an approximately 2-fold increased risk of relapse within 10 years; however, the situation is less clear for other solid tumors such as colon cancer (, ).
Circulating Tumor Cells: Origin, Role, Current Applications, and
网页2024年9月20日 · Circulating tumor cells (CTCs) currently represent a revolutionary tool offering unique insights for the evaluation of cancer progression, metastasis, and response to therapies. Indeed, CTCs, upon detachment from primary tumors, enter the bloodstream and acquire a great potential for their use for personalized cancer management. In this review, we describe the current understanding of and ...
Clinical relevance of cytokeratin-negative circulating tumor cells.
网页2011年5月20日 · Background: Current enrichment techniques rely upon epithelial markers for capture of circulating tumor cells (CTCs). We developed a new method of isolating CTCs that lack EpCAM and/or cytokeratin (CK) expression; presumably cells that have undergone epithelial-to-mesenchymal transition (EMT).
Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal ...
网页2021年3月2日 · Abstract. Purpose: The purpose of this study was to elucidate the relationship between cytokeratin 19 (CK19) expression and levels of circulating tumor cells (CTCs) in preoperative peripheral blood of patients with hepatocellular carcinoma (HCC), and the potential influence of that relationship on prognosis.
Circulating tumour cells lacking cytokeratin in breast cancer: the ...
网页2011年2月25日 · Circulating tumour cells (CTCs) are independent predictor of prognosis in metastatic breast cancer. Nevertheless, in one third of patients, circulating tumour cells are undetected by conventional methods.
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