CTIP2 and lipid metabolism: regulation in skin development and ...
网页COUP-TF INTERACTING PROTEIN 2 (CTIP2) is a crucial transcription factor exhibiting its control through coupled modulation of epigenetic modification and transcriptional regulation of key genes related to skin, immune, and nervous system development.
Ctip2 is a dynamic regulator of epidermal proliferation and ...
网页2012年12月1日 · Ctip2 expression is regulated by EGF–EGFR signaling in proliferating cells and by calcium signaling in differentiated keratinocytes. Ctip2 and EGFR are highly expressed in keratinocytes at E14.5 and loss of Ctip2 resulted in a dramatic downregulation of EGFR expression.
Unc5C and DCC act downstream of Ctip2 and Satb2 and …
网页2014年4月17日 · We show that the expression of two Netrin1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively. Further, we show that the Netrin1–Unc5C/DCC interaction...
Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse …
网页COUP-TF-interacting protein 2 (CTIP2), also known as Bcl11b, is a transcriptional regulatory protein that is highly expressed in and plays a critical role (s) during development of T lymphocytes and the central nervous system. We demonstrate herein that CTIP2 is also highly expressed in mouse skin during embryogenesis and in adulthood as ...
Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System
网页2020年12月10日 · Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions.
Ctip2 Controls the Differentiation of Medium Spiny Neurons and …
网页2008年1月16日 · Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington's disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development.
Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System - PubMed
网页2020年12月10日 · Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions.
CTIP2-Regulated Reduction in PKA-Dependent DARPP32 …
网页2019年9月10日 · In this article, Fjodorova and colleagues provide mechanistic and potential therapeutic insight into striatal neurodegeneration caused by CTIP2 hypofunction. CTIP2 plays an essential role in human MSN homeostasis via regulating PKA-dependent DARPP32 phosphorylation and protecting MSNs from oxidative stress-induced cell death.
[CTIP2, a multifunctional protein: cellular physiopathology and ...
网页The transcription factor CTIP2 (BCL11B) is a multifunctional protein involved in numerous cell physiological processes. To date, many molecular mechanisms underlying this process have been discovered, which highlighted the importance of the epigenetic regulation of genes and the regulation of the el ….
神经元和胶质细胞标记物 | Cell Signaling Technology
网页路易氏小体是一种 PD 病理标记物，其特点是有 α-突触核蛋白内含物，可导致多巴胺能神经元缺失。. PTEN 诱导假定激酶 1 (PINK1) 和亮氨酸富集重复序列激酶 2 (LRRK2) 是在家族性 PD 中可发生突变的激酶。. 影响上位和下位运动神经元的 ALS 与超氧化物歧化酶 1 (SOD1 ...