Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
网页2020年8月21日 · Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in …
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
网页2022年10月13日 · Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT fibrosis are...
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
网页2020年8月21日 · This article discusses recent research in modeling adipose tissue fibrosis using in vivo and in vitro (2D and 3D) methods with considerations for biomaterial selections. Additionally, this article outlines the importance of adipose tissue in treating other fibrotic diseases and methods used to detect and characterize adipose tissue fibrosis.
Adipose Tissue Fibrosis in Obesity: Etiology and Challenges
网页2022年2月10日 · In this review, we highlight adipose tissue remodeling events shown to be associated with fibrosis deposition, with a focus on adipose progenitors involved in obesity-induced healthy as well as unhealthy WAT expansion.
Adipose tissue fibrosis - PMC - National Center for …
网页2015年5月5日 · Adipose tissue fibrosis limits healthy growth of adipose tissue and is associated with metabolic complications in obesity. Hypoxia and subsequent activation of HIF-1 initiate profibrotic mechanisms in fat tissues.
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance …
网页2020年8月21日 · Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in …
Fibrosis and Adipose Tissue Dysfunction - PMC - National …
网页2013年10月1日 · Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent pro-fibrotic transcriptional program.
Unravelling adipose tissue fibrosis in obesity | Nature Reviews ...
网页2022年5月10日 · In obesity, adipose tissue can become inflamed and fibrotic, which contributes to insulin resistance. A new study in Nature Metabolism uncovers a role for peptidase D (PEPD), an important...
Adipose Tissue Fibrosis in Obesity: Etiology and Challenges
网页Although no targeted therapy yet exists to slow or reverse adipose tissue fibrosis, a number of findings have clarified the underlying cellular and molecular mechanisms. In this review, we highlight adipose tissue remodeling events shown to be associated with fibrosis deposition, with a focus on adipose progenitors involved in obesity-induced ...
The adipokine orosomucoid alleviates adipose tissue fibrosis …
网页2021年4月19日 · The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder...
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