Forcing cells into shape: the mechanics of actomyosin contractility
网页Actomyosin-mediated contractility is a highly conserved mechanism for generating mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and tissue morphogenesis. Whereas actomyosin-mediated contractility in striated muscle is well understood, the regulation of such contractility in non-muscle and ...
ACTOMYOSIN COMPLEX - PMC - National Center for …
网页The actin-myosin complex is a molecular partnership that sustains the existence of eukaryotes, ranging from amoebas to humans. This wide phylogenetic distribution reflects the functional importance of actomyosin interactions.
Optogenetic relaxation of actomyosin contractility uncovers mechanistic ...
网页2021年12月8日 · Actomyosin contractility underlies force generation in a wide range of cellular and tissue morphogenesis in animals. Prominent examples include the tail retraction of...
网页2015年7月1日 · Abstract | Actomyosin-mediated contractility is a highly conserved mechanism for generating mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and...
The Actomyosin Cortex of Cells: A Thin Film of Active Matter
网页2021年1月19日 · The actomyosin cortex is a thin film, containing actin filaments and myosin molecular motors, located beneath the plasma-membrane of eukaryotic cells. Active processes, driven by ATP hydrolysis, can generate mechanical forces in the cortex. Coordinated force-generation drives large-scale mechanical flows and orientation patterns.
The biochemical composition of the actomyosin network sets the ...
网页2021年8月8日 · The regulation of cellular force production relies on the complex interplay between a well-conserved set of proteins of the cytoskeleton: actin, myosin, and α-actinin. Despite our deep knowledge of the role of these proteins in force production at the molecular scale, our understanding of the biochemical regulation of the magnitude of traction ...
Actomyosin Complex - PubMed
网页Formation of cross-bridges between actin and myosin occurs ubiquitously in eukaryotic cells and mediates muscle contraction, intracellular cargo transport, and cytoskeletal remodeling. Myosin motors repeatedly bind to and dissociate from actin filaments in a cycle that transduces the chemical energy ….
Principles of Actomyosin Regulation In Vivo - Cell Press
网页2018年10月29日 · Which components of the actomyosin machinery are used to build each of the actomyosin structures found in vivo, and what is their unique architecture? What are the genetic and mechanical factors responsible for the spatial and temporal regulation of Rho GTPase signaling in different developmental contexts?
High-resolution structures of the actomyosin-V complex in three …
网页2021年11月23日 · The structures reveal a high flexibility of myosin in each state and provide valuable insights into the structural transitions of myosin-V upon ADP release and binding of AppNHp, as well as the actomyosin interface. In addition, they show how myosin is able to specifically alter the structure of F-actin.
Forcing cells into shape: the mechanics of actomyosin contractility ...
网页2015年7月1日 · Actomyosin-mediated contractility is a highly conserved mechanism for generating mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and...